2006-2007 Publications
Brandman O, Liou J, Park WS, Meyer T. (2007) STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell. 131 (7): 1327-39. [PubMed]
Poon AC, Ferrell JE Jr. (2007) Systems biology. A clock with a flip switch. Science 318 (5851): 757-8. [PubMed]
Swigut T, Wysocka J. (2007) H3K27 Demethylases, at Long Last. Cell 131 (1): 29-32. [PubMed]
Maynard-Smith LA, Chen LC, Banaszynski LA, Ooi AG, Wandless TJ. (2007) A directed approach for engineering conditional protein stability using biologically silent small molecules. J Biol Chem 282 (3): 24866-72. [PubMed]
Shestopalov IA, Shinha S, Chen JK. (2007) Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 3 (10): 650-1. [PubMed]
Qi X, Vallentin A, Churchill E, Mochly-Rosen D. (2007) deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. J Mol Cell Cardiol 43 (4): 420-8. [PubMed]
Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. (2007) Rescue of Degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem 8 (10): 1162-9. [PubMed]
Paulsen RD, Cimprich KA. (2007) The ATR pathway: fine-tuning the fork. DNA Repair (AMST). 6 (7): 953-66. [PubMed]
Liou J, Fivaz M, Inoue T, Meyer T. (2007) Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci USA 104 (22): 9301-6. [PubMed]
Sellmyer, M. A.; Stankunas, K.; Briesewitz, R.; Crabtree, G. R.; Wandless, T. J. (2007) Engineering Small Molecule Specificity in Nearly Identical Cellular Environments. Bioorg. Med. Chem. Lett 17 (10): 2703-2705. [PubMed]
Edwards SR, Wandless TJ. (2007) The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem 282 (18): 13395-401. [PubMed]
Bright R, Steinberg GK, Mochly-Rosen D. (2007) DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res. 1144: 1146-55. [PubMed]
Budas GR, Churchill EN, Mochly-Rosen D. (2007) Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. Pharmacol Res. 55 (6): 523-536. [PubMed]
MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. (2007) The structural determinants of checkpoint activation. Genes Dev. 21 (8): 879-85. [PubMed]
Kim SY, Ferrell JE Jr. (2007) Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 128 (6): 1133-45. [PubMed]
Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. (2007) Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovasc Res. 73 (4): 699-709. [PubMed]
Serber Z, Ferrell JE Jr. (2007) Tuning bulk electrostatics to regulate protein function. Cell 128 (3): 519-31. [PubMed]
Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. (2007) Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. J Biol Chem 282 (6): 4113-23. [PubMed]
Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA. (2007) Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells. Biochem Biophys Res Commun. 352 (2): 423-30. [PubMed]
Vallentin A, Mochly-Rosen D. (2007) RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem 282 (3): 1650-7. [PubMed]
Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. (2007) A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells. Cell Cycle 6 (18): 2276-83. [PubMed]
Cimprich KA. (2007) Probing ATR activation with model DNA templates. Cell Cycle 6 (19): 2348-54. [PubMed]
Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. (2007) Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 43 (4): 517-22. [PubMed]
Grimley JS, Sawayama AM, Tanaka H, Stohlmeyer MM, Woiwode TF, Wandless TJ. (2007) The enantioselective synthesis of phomopsin B. Angew Chem Int Ed Engl. 46 (43): 8157-9. [PubMed]
Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. (2007) Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem Soc Trans. 35: 1021-6.
Churchill EN, Mochly-Rosen D. (2007) The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans. 35 (5): 1040+2. [PubMed]
Budas GR, Mochly-Rosen D (2007) Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage. Biochem Soc Trans. 35 (5): 1052-4. [PubMed]
Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. (2007) siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol. 8 (7): R142. [PubMed]
Stone M, Jia s, Heo WD,Meyer T, Konan KV. (2007) Participation of rab5,an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol 81 (9): 4551-63. [PubMed]
Lupardus PJ, Van C. Cimprich Ka. (2007) Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods 41 (2): 222-31. [PubMed]
Ubersax JA, Ferrell JE Jr. (2007) Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol. 8 (7): 530-41. [PubMed]
Shimohata T, Zhao H, Sung JH,Sun G, Mochly-Rosen D, Steinberg GK (2007) Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J Cereb Blood Flow Metab. 27 (8): 1463-75. [PubMed]
Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. (2007) Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. J Mol Cell Cardiol 42 (4): 835-41. [PubMed]
Siwko S, Mochly-Rosen D. (2007) Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. Int J Biochem Cell Biol. 39 (5): 978-87. [PubMed]
Kheifets V, Mochly-Rosen D. (2007) Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res. 55 (6): 467-476. [PubMed]
Berdeaux, R.; Goebel, N., Banaszynski, L, A.; Takemori, H.; Wandless, T. J.; Shelton, G. D.; Montminy, M. SIK1 is a Class II HDAC Kinase that Promotes Survival of Skeletal Myocytes. (2007) SIK1 is a Class II HDAC Kinase that Promotes Survival of Skeletal Myocytes. Nature Medicine 13: 597-603.
Esengil, H., Chang, V., Mich, J.K., and Chen, J.K. (2007) Small-molecule regulation of zebrafish gene expression. Nature Chemical Biology 3: 154-5. [PubMed]
Serber Z, Selenko P, Hansel R, Reckel S, Lohr F, Ferrell JE Jr, Wagner G, Dotsch V. (2006) Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy. Nat Protoc. 1 (6): 2701-9. [PubMed]
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