2008-2009 Publications
Ferrell JE Jr, Pomerening JR, Kim SY, Trunnell NB, Xiong W, Huang CY, Machleder EM. (2009)Simple and realistic models of complex biological processess: A cell-fate switch and the mitotic trigger. FEBS Lett. Oct 28 [PubMed]
Driscoll R, Cimprich KA. (2009) HARPing on abount the DNA damage response during replication. Genes Dev. Oct 15:23(20): 2359-65 [PubMed]
Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. 2009 Ischemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion. Cardiovasc Res. Oct 10. [PubMed]
Ouyang X, Shestopalov IA, Sinha S, Zheng G, Pitt CL, Li WH, Olsen AH, Chen JK. (2009) Versatile Synthesis and Rational Design of Caged Morpholinos. J Am Chem Soc. Aug 26 [PubMed]
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc Natl Acad Sci USA. Aug 18;106(33): 14132-7 [PubMed]
Paulsen RD, Soni DV, Wollman R, Hahn AT, Yee MC, Guan A, Hesley HJA, Miller SC, Cromwell EF, Solow-Cordero DE, Meyer T, Cimprich KA.(2009) A genome-wide siRNA screen reveals diverse cellular processess and pataheays that mediate genome stability. Mol Cell. Jul 31;35(2):228-39 [PubMed]
Ferrell JE Jr. Q&A: Cooperativity Jun 16;8(6):53 [PubMed]
Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. (2009) Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res. May 1;82(2):229-39. [PubMed]
Justman QA, Serber Z, Ferrell JE Jr, El-Samad H, Shokat KM. (2009) Tuning the activation threshold of a kinase network by nested feedback loops. Science. Apr 24;324(5926):509-12.
Swigut T, Wysocka J. Cell. (2009) Fallen immortal. Apr 17; 137(2):203-5. [PubMed]
Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. Dev Biol. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Dev Biol. Apr 15; 328(2):342-54.[PubMed]
Yang H, Xiang J, Wang N, Zhao Y, Hyman J, Jiang J, Chen JK, Yang Z, Lin S. (2009) Converse conformational control of smoothened activity by structurally related small molecules. J Biol Chem. Apr 14. [PubMed]
Hahn AT, Jones JT, Meyer T. (2009) Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle. Apr 2;8(7) [PubMed]
Lim DA, Huang YC, Swigut T, Mirick AL, Garcia-Verdugo JM, Wysocka J, Ernst P, Alvarez-Buylla A. (2009) Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature. Mar 26;458(7237):529-33. [PubMed]
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. (2009). A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol Mar;5(3):154-6 [PubMed]
Churchill EN, Disatnik MH, Mochly-Rosen D. (2009) Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of varepsilonPKC and activation of aldehyde dehydrogenase 2. J Mol Cell Cardiol. Feb; 46(2):278-84. [PubMed]
Chang DJ, Cimprich KA. (2009). DNA damage tolerance: when it's OK to make mistakes. Nat Chem Biol. Feb;5(2):82-90. [PubMed]
Ferrell JE Jr. (2009) Q&A: Systems biology. J Biol. Jan 26;8(1):2.
Ratomski K, Zak J, Kasprzycka E, Hryniewicz K, Wysocka J. (2009) Cytometric evaluation of immaturity granulocytes in infections. Pol Merkur Lekarski. Jan;26(151):14-8. Polish [PubMed]
Wandless TJ. (2009) The proteasome makes sense of mixed signals. Nat Chem Biol. 2009 Jan;5(1):3-4. [PubMed]
Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew Chem Int Ed Engl. 48(13):2321-4. [PubMed]
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Palaniyandi SS, Inagaki K, Mochly-Rosen D. (2008) Mast cells and varepsilonPKC: A role in cardiac remodeling in hypertension-induced heart failure. J Mol Cell Cardiol. Dec; 45(6):779-86 [PubMed]
Chu BW, Banaszynski LA, Chen LC, Wandless TJ. (2008) Recent progress with FKBP-derived destabilizing domains. Bioorg Med Chem Lett. Nov 15;18(22):5941-4 [PubMed]
Pomerening JR, Ubersax JA, Ferrell JE Jr. (2008) Rapid Cycling and Precocious Termination of G1 Phase in Cells Expressing CDK1AF. Mol Biol Cell Aug;19(8):3426-41[PubMed]
Ciimprich KA, Cortez D.(2009) ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol. 2008 Aug;9(8):616-27.[PubMed]
Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE Jr. (2008) Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops. Science Jul 4; 321 (5885): 126-129. [PubMed]
Chen JK, (2008) Fish 'n clicks. Nat Chem Biol. Jul;4(7):391-2 [PubMed]
Ferrell, JE, Jr. (2008) Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol. Mar 25; 18 (6): R244-5. [Pub?Med]
Castañeda D, Zhao H, Mochly-Rosen D, Steinberg GK. (2008) Activating deltaPKC antagonizes the protective effect of ERK1/2 inhibition against stroke in rats. Brain Res. Jan 28;1251:256-61 [PubMed]
Santos SD, Ferrell JE. (2008) Systems biology: On the cell cycle and its switches. Nature Jan 26; 454 (7202): 288-9. [PubMed]
Churchill EN, Qvit N, Mochly-Rosen D. (2008) Rationally designed peptide regulators of protein kinase C. Trends Endocrinol Metab. Trends Endocrinol Metab. Jan;20(1):25-33 [PubMed]
Churchill EN, Disatnik MH, Budas GR, Mochly-Rosen D. (2008) Ethanol for cardiac ischemia: the role of protein kinase c. Ther Adv Cardiovasc Dis. 2 (6): 469-83. [PubMed]
Vitorino P, Meyer T. (2008) Modular control of endothelial sheet migration. Genes Dev. 22 (23): 3268-81. [PubMed]
Brandman O, Meyer T. (2008) Feedback loops shape cellular signals in space and time. Science 322 (5900): 390-5. [PubMed]
Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH. (2008) Chemical control of protein stability and function in living mice. Nat Med. 14 (10): 1123-7. [PubMed]
Chen CH, Budas GR, Churchill EN, Disatnik MH, Hurley TD, Mochly-Rosen D. (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321 (5895): 1493-5. [PubMed]
Chen JK, Hurlstone AF. (2008) Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics. Zebrafish 5 (3): 193-195. [PubMed]
Inoue T, Meyer T. (2008) Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration. PLoS ONE 3 (8): 3068. [PubMed]
Kim J, Choi YL, Vallentin A, Hunrichs BS, Hellerstein MK, Peehl DM, Mochly-Rosen D. (2008) Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis. Cancer Res. 68 (16): 6831-9. [PubMed]
Shestopalov IA, Chen JK. (2008) Chemical technologies for probing embryonic development. Chem Soc Rev. 37 (7): 391-2. [PubMed]
Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. (2008) Alteration of gene expression during progression of hypertension-induced cardiac dysfunction in rats. Am J Physiol Heart Circ Physiol. [PubMed]
Kaplan DD, Zimmermann G, Suyama K, Meyer T, Scott MP. (2008) A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Br J Cancer. 22 (14): 1877-93. [PubMed]
Cimprich KA, Cortez D. (2008) ATR: an essential regulator of genome integrity. Nat Rev Mol Cell Biol. [PubMed]
Low WC, Wang C, Pan Y, Huang XY, Chen JK, Wang B. (2008) The decoupling of Smoothened from Galpha(i) proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev Biol. [PubMed]
Inagaki K, Koyanagi T, Berry NC, Sun L, Mochly-Rosen D. (2008) Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failure. Hypertension 51 (6): 1565-9. [PubMed]
Bright R, Sun GH, Yenari MA, Steinberg GK, Mochly-Rosen D. (2008) varepsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury. Neurosci Lett. [PubMed]
Abe N, Inoue T, Galvez T, Klein L, Meyer T. (2008) Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci. 121 (9): 1488-94. [PubMed]
Guignet EG, Meyer T. (2008) Suspended-drop electroporation for high-throughput delivery of biomolecules into cells. Nat Methods. 5 (5): 393-5. [PubMed]
Peng J, Wysocka J. (2008) It takes a PHD to SUMO. Trends Biochem Sci. 33 (5): 191-4. [PubMed]
Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. (2008) Alteration of Gene Expression During Progression of Hypertension-induced Cardiac Dysfunction in Rats. Am J Physiol Heart Circ Physiol [PubMed]
Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH. (2008) Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane. Mol Biol Cell. [PubMed]
Park WS, Heo WD, Whalen JH, O'Rourke NA, Bryan HM, Meyer T, Teruel MN. (2008) Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell. 30 (3): 529-33. [PubMed]
Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO. (2008) Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS ONE 3 (5): e2126. [PubMed]
Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE Jr. (2008) A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes. Dev Biol. [PubMed]
Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ. (2008) Islet cell survival during isolation improved through protein kinase C epsilon activation. Transplant Proc. 40 (2): 375-8. [PubMed]
Esengil H, Chen JK. (2008) Gene regulation technologies in zebrafish. Mol Biosyst. 4: 300-8. [PubMed]
Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. (2008) Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. Int J CArdiol [PubMed]
Grimley JS, Chen DA, Banaszynski LA, Wandless TJ. (2008) Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 18 (2): 759-61. [PubMed]
Fivaz M, Bandara S, Inoue T, Meyer T. (2008) Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Curr Biol. 18 (1): 44-50. [PubMed]
Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. (2008) Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest 118 (1): 173-82. [PubMed]
Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D (2008) PKC isozymes in chronic cardiac disease: possible therapeutic targets? Annu Rev Pharmacol Toxicol. 48: 569-99. [PubMed]
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