Years: 2007-20082005-20062003-20042001-2002

Koyanagi T, Wong LY, Inagaki K, Petrauskene OV, Mochly-Rosen D. (2008) Alteration of Gene Expression During Progression of Hypertension-induced Cardiac Dysfunction in Rats. Am J Physiol Heart Circ Physiol [PubMed]

Chae YC, Kim JH, Kim KL, Kim HW, Lee HY, Heo WD, Meyer T, Suh PG, Ryu SH. (2008) Phospholipase D Activity Regulates Integrin-mediated Cell Spreading and Migration by Inducing GTP-Rac Translocation to the Plasma Membrane. Mol Biol Cell. [PubMed]

Pomerening JR, Ubersax JA, Ferrell JE Jr. (2008) Rapid Cycling and Precocious Termination of G1 Phase in Cells Expressing CDK1AF. Mol Biol Cell [PubMed]

Park WS, Heo WD, Whalen JH, O'Rourke NA, Bryan HM, Meyer T, Teruel MN. (2008) Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell. 30 (3): 529-33. [PubMed]

Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO. (2008) Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS ONE 3 (5): e2126. [PubMed]

Reich SG, Meyer T. (2008) Teaching video NeuroImage: Spasmodic dysphonia: adductor and abductor. Neurology 70 (19) [PubMed]

Karahaliou PK, Kouwer PH, Meyer T, Mehl GH, Photinos DJ. (2008) Long- and Short-Range Order in the Mesophases of Laterally Substituted Calamitic Mesogens and their Radial Octapodes. J Phys Chem B. 112 (21): 6550-6. [PubMed]

Ferrell, JE, Jr. (2008) Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr Biol. 18 (6): R244-5. [PubMed]

Ríos-Cardona D, Ricardo-González RR, Chawla A, Ferrell JE Jr. (2008) A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes. Dev Biol. [PubMed]

Kvezereli M, Vallentin A, Mochly-Rosen D, Busque S, Fontaine MJ. (2008) Islet cell survival during isolation improved through protein kinase C epsilon activation. Transplant Proc. 40 (2): 375-8. [PubMed]

Esengil H, Chen JK. (2008) Gene regulation technologies in zebrafish. Mol Biosyst. 4: 300-8. [PubMed]

Kaneda H, Ikeno F, Inagaki K, Mochly-Rosen D. (2008) Preserved coronary endothelial function by inhibition of delta protein kinase C in a porcine acute myocardial infarction model. Int J CArdiol [PubMed]

Grimley JS, Chen DA, Banaszynski LA, Wandless TJ. (2008) Synthesis and analysis of stabilizing ligands for FKBP-derived destabilizing domains. Bioorg Med Chem Lett. 18 (2): 759-61. [PubMed]

Fivaz M, Bandara S, Inoue T, Meyer T. (2008) Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Curr Biol. 18 (1): 44-50. [PubMed]

Qi X, Inagaki K, Sobel RA, Mochly-Rosen D. (2008) Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats. J Clin Invest 118 (1): 173-82. [PubMed]

Pham NM, Recht NS, Hostetter TH, Meyer TW. (2008) Removal of the protein-bound solutes indican and p-cresol sulfate by peritoneal dialysis. Clin J Am Soc Nephrol 3 (1): 85-90. [PubMed]

Swarbreck D, Wilks C, Lamesch P, Berardini TZ, Garcia-Hernandez M, Foerster H, Li D, Meyer T, (2008) The Arabidopsis Information Resource (TAIR): gene structure and function annotation. Nucleic Acids Res. 36: D1009-14. [PubMed]

Churchill E, Budas G, Vallentin A, Koyanagi T, Mochly-Rosen D (2008) PKC isozymes in chronic cardiac disease: possible therapeutic targets? Annu Rev Pharmacol Toxicol. 48: 569-99. [PubMed]

Brandman O, Liou J, Park WS, Meyer T. (2007) STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels. Cell. 131 (7): 1327-39. [PubMed]

Poon AC, Ferrell JE Jr. (2007) Systems biology. A clock with a flip switch. Science 318 (5851): 757-8. [PubMed]

Swigut T, Wysocka J. (2007) H3K27 Demethylases, at Long Last. Cell 131 (1): 29-32. [PubMed]

Meyer TW, Hostetter TH. (2007) Uremia N Engl J Med. 357 (13): 1316-25. [PubMed]

Maynard-Smith LA, Chen LC, Banaszynski LA, Ooi AG, Wandless TJ. (2007) A directed approach for engineering conditional protein stability using biologically silent small molecules. J Biol Chem 282 (3): 24866-72. [PubMed]

Shestopalov IA, Shinha S, Chen JK. (2007) Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 3 (10): 650-1. [PubMed]

Qi X, Vallentin A, Churchill E, Mochly-Rosen D. (2007) deltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. J Mol Cell Cardiol 43 (4): 420-8. [PubMed]

Stankunas K, Bayle JH, Havranek JJ, Wandless TJ, Baker D, Crabtree GR, Gestwicki JE. (2007) Rescue of Degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. Chembiochem 8 (10): 1162-9. [PubMed]

Paulsen RD, Cimprich KA. (2007) The ATR pathway: fine-tuning the fork. DNA Repair (AMST). 6 (7): 953-66. [PubMed]

Liou J, Fivaz M, Inoue T, Meyer T. (2007) Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci USA 104 (22): 9301-6. [PubMed]

Sellmyer, M. A.; Stankunas, K.; Briesewitz, R.; Crabtree, G. R.; Wandless, T. J. (2007) Engineering Small Molecule Specificity in Nearly Identical Cellular Environments. Bioorg. Med. Chem. Lett 17 (10): 2703-2705. [PubMed]

Edwards SR, Wandless TJ. (2007) The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain. J Biol Chem 282 (18): 13395-401. [PubMed]

Bright R, Steinberg GK, Mochly-Rosen D. (2007) DeltaPKC mediates microcerebrovascular dysfunction in acute ischemia and in chronic hypertensive stress in vivo. Brain Res. 1144: 1146-55. [PubMed]

Budas GR, Churchill EN, Mochly-Rosen D. (2007) Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury. Pharmacol Res. 55 (6): 523-536. [PubMed]

Kainz A, Perco P,Mayer B, Soleiman A, Steinger R, Mayer G, Mitterbauer C, Schwarz C, Meyer TW, Oberbauer R. (2007) Gene-expression profiles and age of donor kidney biopsies obtained before transplantation distinguish medium term graft function. Transplantation 83 (8): 1048-54. [PubMed]

MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA. (2007) The structural determinants of checkpoint activation. Genes Dev. 21 (8): 879-85. [PubMed]

Kim SY, Ferrell JE Jr. (2007) Substrate competition as a source of ultrasensitivity in the inactivation of Wee1. Cell 128 (6): 1133-45. [PubMed]

Ikeno F, Inagaki K, Rezaee M, Mochly-Rosen D. (2007) Impaired perfusion after myocardial infarction is due to reperfusion-induced deltaPKC-mediated myocardial damage. Cardiovasc Res. 73 (4): 699-709. [PubMed]

Serber Z, Ferrell JE Jr. (2007) Tuning bulk electrostatics to regulate protein function. Cell 128 (3): 519-31. [PubMed]

Brandman R, Disatnik MH, Churchill E, Mochly-Rosen D. (2007) Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces. J Biol Chem 282 (6): 4113-23. [PubMed]

Mamidipudi V, Miller LD, Mochly-Rosen D, Cartwright CA. (2007) Peptide modulators of Src activity in G1 regulate entry into S phase and proliferation of NIH 3T3 cells. Biochem Biophys Res Commun. 352 (2): 423-30. [PubMed]

Vallentin A, Mochly-Rosen D. (2007) RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem 282 (3): 1650-7. [PubMed]

Stone M, Jia S, Heo WD, Meyer T, Konan KV. (2007) Participation of rab5, an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol 81 (9): 4551-63. [PubMed]

Burney RO, Lee AI, Leong DE, Jones JT, Hahn AT, Meyer T, Yao MW. (2007) A transgenic mouse model for high content, cell cycle phenotype screening in live primary cells. Cell Cycle 6 (18): 2276-83. [PubMed]

Cimprich KA. (2007) Probing ATR activation with model DNA templates. Cell Cycle 6 (19): 2348-54. [PubMed]

Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. (2007) Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 43 (4): 517-22. [PubMed]

Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D. (2007) Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 43 (4): 517-22.

Grimley JS, Sawayama AM, Tanaka H, Stohlmeyer MM, Woiwode TF, Wandless TJ. (2007) The enantioselective synthesis of phomopsin B. Angew Chem Int Ed Engl. 46 (43): 8157-9. [PubMed]

Budas GR, Koyanagi T, Churchill EN, Mochly-Rosen D. (2007) Competitive inhibitors and allosteric activators of protein kinase C isoenzymes: a personal account and progress report on transferring academic discoveries to the clinic. Biochem Soc Trans. 35: 1021-6.

Churchill EN, Mochly-Rosen D. (2007) The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans. 35 (5): 1040+2. [PubMed]

Budas GR, Mochly-Rosen D (2007) Mitochondrial protein kinase Cepsilon (PKCepsilon): emerging role in cardiac protection from ischaemic damage. Biochem Soc Trans. 35 (5): 1052-4. [PubMed]

Galvez T, Teruel MN, Heo WD, Jones JT, Kim ML, Liou J, Myers JW, Meyer T. (2007) siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol. 8 (7): R142. [PubMed]

Stone M, Jia s, Heo WD,Meyer T, Konan KV. (2007) Participation of rab5,an early endosome protein, in hepatitis C virus RNA replication machinery. J Virol 81 (9): 4551-63. [PubMed]

Lupardus PJ, Van C. Cimprich Ka. (2007) Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods 41 (2): 222-31. [PubMed]

Meyer TW, Peattie JW, Miller JD, Dinh DC, Recht NS, Walther JL, Hostetter TH. (2007) Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J AM Soc Nephrol. 18 (3): 675-6. [PubMed]

Ubersax JA, Ferrell JE Jr. (2007) Mechanisms of specificity in protein phosphorylation. Nat Rev Mol Cell Biol. 8 (7): 530-41. [PubMed]

Shimohata T, Zhao H, Sung JH,Sun G, Mochly-Rosen D, Steinberg GK (2007) Suppression of deltaPKC activation after focal cerebral ischemia contributes to the protective effect of hypothermia. J Cereb Blood Flow Metab. 27 (8): 1463-75. [PubMed]

Liron T, Chen LE, Khaner H, Vallentin A, Mochly-Rosen D. (2007) Rational design of a selective antagonist of epsilon protein kinase C derived from the selective allosteric agonist, pseudo-RACK peptide. J Mol Cell Cardiol 42 (4): 835-41. [PubMed]

Siwko S, Mochly-Rosen D. (2007) Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. Int J Biochem Cell Biol. 39 (5): 978-87. [PubMed]

Kheifets V, Mochly-Rosen D. (2007) Insight into intra- and inter-molecular interactions of PKC: design of specific modulators of kinase function. Pharmacol Res. 55 (6): 467-476. [PubMed]

Berdeaux, R.; Goebel, N., Banaszynski, L, A.; Takemori, H.; Wandless, T. J.; Shelton, G. D.; Montminy, M. SIK1 is a Class II HDAC Kinase that Promotes Survival of Skeletal Myocytes. (2007) SIK1 is a Class II HDAC Kinase that Promotes Survival of Skeletal Myocytes. Nature Medicine 13: 597-603.

Esengil, H., Chang, V., Mich, J.K., and Chen, J.K. (2007) Small-molecule regulation of zebrafish gene expression. Nature Chemical Biology 3: 154-5. [PubMed]

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